A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering.
نویسنده
چکیده
The last 50 years of molecular genetics have produced an abundance of new discoveries and data that make it useful to revisit some basic concepts and assumptions in our thinking about genomes and evolution. Chief among these observations are the complex modularity of genome organization, the biological ubiquity of mobile and repetitive DNA sequences, and the fundamental importance of DNA rearrangements in the evolution of sequenced genomes. This review will take a broad overview of these developments and suggest some new ways of thinking about genomes as sophisticated informatic storage systems and about evolution as a systems engineering process.
منابع مشابه
Genome organization and reorganization in evolution: formatting for computation and function.
This volume deals with the role of epigenetics in life and evolution. The most dynamic forms of functional genome formatting involve DNA interacting with cellular complexes that do not alter sequence information. Such important epigenetic phenomena are the main subjects of other articles in this volume. This article focuses on the long-lived form of genome formatting that lies within the DNA se...
متن کاملNATURAL GENETIC ENGINEERING AND NATURAL GENOME EDITING Revisiting the Central Dogma in the 21st Century
Since the elaboration of the central dogma of molecular biology, our understanding of cell function and genome action has benefited from many radical discoveries. The discoveries relate to interactive multimolecular execution of cell processes, the modular organization of macromolecules and genomes, the hierarchical operation of cellular control regimes, and the realization that genetic change ...
متن کاملNothing in Evolution Makes Sense Except in the Light of Genomics: Read–Write Genome Evolution as an Active Biological Process
The 21st century genomics-based analysis of evolutionary variation reveals a number of novel features impossible to predict when Dobzhansky and other evolutionary biologists formulated the neo-Darwinian Modern Synthesis in the middle of the last century. These include three distinct realms of cell evolution; symbiogenetic fusions forming eukaryotic cells with multiple genome compartments; horiz...
متن کاملSustainable regionalism: Reading the sustainability approach in the context of regionalist architecture
The innate sense of interaction with the region is a sign of environmental sensitivity, which is very vital in the 21st century. Today, it is inevitable that regionalism should be included in a larger discourse of architecture, and that the debate over the role of the use of regional green architecture as a factor in cultural identity and sense of place should be promoted. The present study arg...
متن کامل16th century Persian tiles in dialogue with 21st century digital tiles in the Sadrian universe
This article brings together tiles of 16th century Persian architecture and 21st century digital tiles of moving image to explore new potentials beyond the perceived image. As minimal parts of a bigger image, they both appear still and motionless. However, Persian Islamic philosopher, Mulla Sadrā Shirazi’s (1571-1640) theory of ‘substantial motion’ (al-harakat a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Gene
دوره 345 1 شماره
صفحات -
تاریخ انتشار 2005